Nucleic acids biochemistry

Section edited by Albert Jeltsch


This section incorporates all aspects of nucleic acid biochemistry including but not limited to: transcription and translation, chromatin, and replication and repair. 

  1. Research article

    Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity

    Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA meth...

    Olga V. Lukashevich, Natalia A. Cherepanova, Renata Z. Jurkovska, Albert Jeltsch and Elizaveta S. Gromova

    BMC Biochemistry 2016 17:7

    Published on: 22 March 2016

  2. Research article

    The promoter of cell growth- and RNA protection-associated SND1 gene is activated by endoplasmic reticulum stress in human hepatoma cells

    Staphyloccocal nuclease domain-containing protein 1 (SND1) is involved in the regulation of gene expression and RNA protection. While numerous studies have established that SND1 protein expression is modulated...

    Sandra Armengol, Enara Arretxe, Leire Enzunza, Sarai Mula, Begoña Ochoa, Yolanda Chico and María José Martínez

    BMC Biochemistry 2014 15:25

    Published on: 11 December 2014

  3. Research article

    Hepatoma-derived growth factor and nucleolin exist in the same ribonucleoprotein complex

    Hepatoma-derived growth factor (HDGF) is a protein which is highly expressed in a variety of tumours. HDGF has mitogenic, angiogenic, neurotrophic and antiapoptotic activity but the molecular mechanisms by whi...

    Stephanie Bremer, Katharina Klein, Angela Sedlmaier, Mekky Abouzied, Volkmar Gieselmann and Sebastian Franken

    BMC Biochemistry 2013 14:2

    Published on: 10 January 2013

  4. Research article

    Insertion of a myc-tag within α-dystroglycan domains improves its biochemical and microscopic detection

    Epitope tags and fluorescent fusion proteins have become indispensable molecular tools for studies in the fields of biochemistry and cell biology. The knowledge collected on the subdomain organization of the t...

    Simona Morlacchi, Francesca Sciandra, Maria Giulia Bigotti, Manuela Bozzi, Wolfgang Hübner, Antonio Galtieri, Bruno Giardina and Andrea Brancaccio

    BMC Biochemistry 2012 13:14

    Published on: 26 July 2012

  5. Research article

    Bifunctional TaqII restriction endonuclease: redefining the prototype DNA recognition site and establishing the Fidelity Index for partial cleaving

    The TaqII enzyme is a member of the Thermus sp. enzyme family that we propounded previously within Type IIS restriction endonucleases, containing related thermophilic bifunctional endonucleases-methyltransferases...

    Agnieszka Żylicz-Stachula, Olga Żołnierkiewicz, Katarzyna Śliwińska, Joanna Jeżewska-Frąckowiak and Piotr M Skowron

    BMC Biochemistry 2011 12:62

    Published on: 5 December 2011