From: ADP-Ribosylargininyl reaction of cholix toxin is mediated through diffusible intermediates
R to K mutants | R to K replacement mutations on the wild type CTc | ǂ Auto-ADP-ribosylation activity | ¶ NAD + glycohydrolase activity |
---|---|---|---|
M1 | R506K,R566K | 170 | 150.7 ± 1 |
M2 | R426K,R473K,R506K,R566K,R629K | 205 | 173 ± 3.4 |
M4 | R426K,R473K,R506K,R519K,R522K,R566K,R629K | 250 | 197.8 ± 4.6 |
M4392 | R426K,R473K,R506K,R519K,R522K,R540K,R566K,R629K | 113 | 105.4 ± 1 |
M4421 | R426K,R473K,R506K,R519K,R522K,R543K,R566K,R629K | 100 | 79.4 ± 5.9 |
M4781 | R426K,R473K,R479K,R506K,R519K,R522K,R566K,R629K | 130 | 126.6 ± 2 |
M5-2 | R426K,R473K,R506K,R519K,R522K,R540K,R543K,R566K,R629K | 100 | 7.8 ± 1.7 |
M5-4 | R426K,R451K,R473K,R506K,R519K,R522K,R540K,R543K,R566K,R629K | 155 | 8.2 ± 0.8 |
M6 | R426K,R451K,R473K,R506K,R519K,R522K,R535K,R540K,R543K,R566K,R629K | 90 | 9.6 ± 1.8 |
M6781 | R426K,R451K,R473K,R479K,R506K,R519K,R522K,R535K,R540K,R543K,R566K,R629K | 0 | 50 ± 1.5 |
M7 | R426K,R451K,R473K,R506K,R519K,R522K,R525K,R535K,R540K,R543K,R566K,R629K | 70 | 1 ± 3 |
M8 | R426K,R451K,R473K,R479K,R506K,R519K,R522K,R525K,R535K,R540K,R543K,R566K,R629K | 0 | 52.1 ± 1.7 |
WT | *- | 215 | 206.3 ± 8.6 |