Subtype | Responsible gene | Protein (kDa) | Requirement for FANCD2 monoubiquitylation | Function of the protein, etc. | Homologs in | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Yeast | Plant | Fly | Worm | Fish | Amphibian | Human, mouse, chicken | |||||
S. cerevisiae | A. thaliana | D. melanogaster | C. elegans | D. rerio | X. laevis | ||||||
A | FANCA | 163 | + | FA core complex | + [123] | + [124] | + | ||||
B | FANCB | 95 | + | FA core complex | + [123] | + [124] | + | ||||
C | FANCC | 63 | + | FA core complex | + [123] | + [124] | + | ||||
D1 | FANCD1/BRCA2 | 380 | - | RAD51 recruitment | + [135] | + [123] | + [124] | + | |||
D2 | FANCD2 | 155,162 | + | monoubiquitylated protein | + [133] | + [27,125] | + [126] | + [123,127] | + [124] | + | |
E | FANCE | 60 | + | FA core complex | + [123] | + [124] | + | ||||
F | FANCF | 42 | + | FA core complex | + [123] | + [136] | + | ||||
G | FANCG/XRCC9 | 68 | + | FA core complex | + [123] | + [124] | + | ||||
I | not identified | ? | + | ? | |||||||
J | FANCJ/BACH1/BRIP1 | 130 | - | 5′→3′ DNA helicase/ATPase | + [132] | + [126] | + | ||||
L | FANCL/PHF9/POG | 43 | + | FA core complex, E3 ubiquitin ligase | + [134] | + [27,125] | + [123] | + [124] | + | ||
M | FANCM/Hef | 250 | + | FA core complex, ATPase/translocase, DNA helicase motifs | + [27] | + [125] | + [126] | + | |||
N | FANCN/PALB2 | 130 | - | regulation of BRCA2 localization | + | + | + |