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Table 3 Active and substrate binding sites of cystatins

From: Pattern similarity study of functional sites in protein sequences: lysozymes and cystatins

 

HCC

EWC

HCA

HCB

Active site

    

   Segment

L9VGG

L7LGA

I2PGG

M2SGA

   SimConst/Av.Hydroph*

1.00/1.35

0.87/1.80

0.97/1.00

0.55/-0.01

Binding site 1

    

   Segment

Q55IVAG

Q53LVSG

Q46VVAG

Q46VVAG

   SimConst/Av.Hydroph

1.00/0.90

0.70/0.92

0.90/0.95

0.90/0.95

Binding site 2

    

   Segment

V104PWQG

I102PWLN

L73PGQN

L73PHEN

   SimConst/Av.Hydroph

1.00/1.01

0.35/1.95

0.30/0.98

-0.16/0.42

   SimConst/Av.Turn**

1.00/1.05

0.90/0.96

0.56/1.22

0.99/1.06

  1. * Pattern similarity constant / average hydrophobicity
  2. ** Pattern similarity constant / average turn propensity
  3. Similar to the corresponding tables for lysozymes (Tables 1 and 2), Sim/Const is 1.0 for reference HCC, and the greater the Av.Property the greater the property strength.
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BMC Biochemistry

ISSN: 1471-2091

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