Inhibitor | Ki(μM) | k2(10-3s-1) | ki(103 M-1s-1) |
---|---|---|---|
(1R, αR)-1 | 0.20 ± 0.01 | 2.0 ± 0.2 | 10 ± 1 |
(1R, gαS)-1 | 0.50 ± 0.03 | 2.0 ± 0.2 | 4.0 ± 0.4 |
(1S, gαR)-1 | 2.0 ± 0.1 | 2.0 ± 0.2 | 1.0 ± 0.1 |
(1S, gαS)-1 | 6.0 ± 0.4 | 1.8 ± 0.2 | 0.30 ± 0.03 |
(R)-2a | 0.8 ± 0.1 | 10 ± 1 | 12 ± 2 |
(S)-2a | 1.3 ± 0.1 | 6.0 ± 0.5 | 5.0 ± 0.6 |