From: Archazolid and apicularen: Novel specific V-ATPase inhibitors
Cell line | Origin | ArcA | ArcB | ApiA | ApiB | BafA1 | ConA |
---|---|---|---|---|---|---|---|
IC50 (nM) | |||||||
L-929 | murine connective tissue | 0.81a | 1.1a | 4.5 | 620 | 3.2a | 0.23a |
3Y1 | rat, embryogenic fibroblast cell line | 0.95 | 1.1 | 3.2 | 310 | 5.6 | 1.4 |
KB-V1b | human cervix carcinoma | 48.0 | 35.0 | 23.0 | 1600 | 7.2 | 28.0 |
KB-V1b | (in presence of 11 μM verapamil) | 2.3 | 1.5 | 7.9 | 540 | 4.0 | 2.7 |
A-594 | human lung carcinoma | 0.54 | 0.69 | 0.23c | 310c | 0.4 | 0.17 |
M1 | mouse, embryogenic fibroblast cell line | 0.27 | 0.35 | 1.4 | 190 | 2.6 | 0.56 |