Effect of alpha-tocopherol on pulmonary antioxidant defence system and lipid peroxidation in cigarette smoke inhaling mice

Table 1 Effect of cigarette smoke and/ or AT on pulmonary antioxidant defence system in male balb/c mice over 2 weeks of treatment

Parameters	Sham	Smoked	AT	Smoked + AT
LPO	16.05 ± 0.56	16.24 ± 0.49	15.72 ± 0.52	15.91 ± 0.68
GSH	3.04 ± 0.06	2.92 ± 0.06	3.03 ± 0.08	2.96 ± 0.03
Catalase	30.40 ± 0.99	33.19 ± 1.24	32.61 ± 1.12	35.24 ± 2.35
GSH-Px	10.02 ± 0.27	10.01 ± 0.32	9.42 ± 0.29	9.52 ± 0.29
GR	7.40 ± 0.40	8.56 ± 0.28^a₁	8.51 ± 0.33^c₁	9.26 ± 0.22^b₁^d₁
SOD	2.90 ± 0.12	2.92 ± 0.66	2.60 ± 0.38	2.79 ± 0.53

Values are in mean ± SD, n = 6–8 ^* Units are expressed as follows : Catalase (I.U. mg protein^-1); GSH-Px and GR (nmol NADPH consumed min^-1 mg protein ^-1); GSH (μmol g tissue^-1); SOD (I.U. mg protein^-1); LPO (nmol malondialdehyde mg protein^-1 30 min^-1). Statistical analysis^aSham vs. Smoked, ^bAT vs. AT + Smoked, ^cSham vs. AT, ^dSmoked vs. AT + Smoked a₁, b₁, c₁, d₁ : p < 0.05; a₂, b₂, c₂, d₂ : p < 0.01; a₃, b₃, c₃, d₃ : p < 0.001.

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