Figure 7

Schematics of proposed models of the Mcm4/6/7 hexamer and the Mcm2-7 double-hexamer. (A) Summary of interactions identified in this report. Double arrows: reciprocal interactions. Single arrows: unidirectional interactions. Hallow arrows: weak interactions. Solid lines: stable homogeneous oligomeric states, such as dimers. Dashed lines: heterogeneous oligomeric states: such as aggregates. (B) Model of the Mcm4/6/7 hexamer. This model is based on the interactions identified in Panel A, which is consistent with the model proposed previouslyfor S. cerevisiae MCM [26], and human MCM [23, 24, 42]. (C-D) Model of hexamer-hexamer interactions for the Mcm2-7 double-hexamer. This model is based on Figure 1A of [6], showing a proposed Mcm7/7 interaction that locks the orientation of two hexamers. The convex and the concave on each subunit in this figure represent the P-loop of the Walker A motif and the Arg-finger motif, respectively.