Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation

BMC Biochemistry

Table 2 Distribution of the structural element fractions for native and glycated insulin along time obtained by deconvolution of CD spectra using CDSSTR algorithm available on Dichroweb (Dichroweb; http://www.cryst.bbk.ac.uk/cdweb/html/home.html) [69, 70].

[MGO] (mM)	Time (h)	α-Helix	β-Sheet	β-Turns	Unordered structure	NRMSD
0	0	31	23	22	24	0.028
	24	33	23	21	23	0.033
	48	32	22	22	24	0.029
1	0	31	24	21	24	0.027
	24	28	26	22	26	0.032
	48	24	27	22	27	0.036
5	0	32	22	22	24	0.022
	24	23	27	21	27	0.029
	48	23	28	21	27	0.035

ISSN: 1471-2091