Figure 5From: Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cellsCdk5 phosphorylates PXR in vitro. Kinase assays were performed as described under Methods. Histone H1 (H1) was the positive and GST the negative control. The amount of substrates loaded to PAGE (substrate inputs) was illustrated by SimplyBlue staining. M, molecular weight marker.Back to article page