Figure 1
From: Prion protein self-peptides modulate prion interactions and conversion
PrPC secondary structures and relative peptide positions versus peptide-array binding pattern and binding domain positions. Schematic representation of PrPC showing signal sequences, β-sheets (S1, S2), α-helices (H1, H2, H3), disulfide bridge (S-S), glycosylation sites (CHO) and the relative positions of the peptides used in this study. The bar graph represents the previously determined peptide-array binding pattern [15] and the relative positions of the determined interaction domains: 1 [27-RPKPGGG-33], A-E octarepeat motif [PxGG], 2 [102-WNK-104], 3 [140-PLIHFGNDY-148], 4a [152-YYR-154], 4b [165-YYR-167], 5 [177-NFV-179] and 6 [225-SQAY-228]. All numbering used is for sheep PrP.